Sickle Cell Disease Ontology Project

BCL11A

http://scdontology.h3abionet.org/ontology/SCDO_0000094

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

Term info

curator note

Request inclusion into relevant ontology, Link to "Hereditary Persistence of fetal hemoglobin".

definition source

http://www.ncbi.nlm.nih.gov/gene/53335

existence in other ontologies

Not relevant to context of sickle cell

BAF Chromatin Remodeling Complex Subunit BCL11A Gene, BCL-11A Gene, B-cell CLL/lymphoma 11A Gene, BCL11A Gene, B-Cell CLL/Lymphoma 11A Gene, HBFQTL5, Fetal Hemoglobin Quantitative Trait Locus 5, B-cell CLL/lymphoma 11A (zinc finger protein)

Term relations

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